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We like kids, baby animals and pretty girls because they have big eyes and big heads.
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The first really appealing cartoons - that really looked like our modern conceptions of cartoons had very big eyes.
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I can admire this kind of drawing for its technical skill but it doesn't attract my eye as quickly as an unrealistic simple, well designed big-eyed, big headed cartoon character. This cartoon from the 1800s is a slight distortion of reality, instead of a complete stylization intended for visual fun and appeal.
Big eyes and big heads are not the only elements that make a cartoon appealing of course, but they are probably the most important elements.
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One thing that drew me to Clampett's cartoons so quickly was how appealing they looked. He drew not only bigger eyes than the other directors, but the huge eyes were much more expressive. They suck you in to the characters' feelings more and invite your empathy.
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Small craniums, small eyes not appealing
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He drew tiny eyes and really tiny craniums, with big jowls - as if he was predicting Fox News Anchors 50 years before their time.
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There is more than 1 school of animation design that fights character emotions by drawing tiny pinpoint eyes. These pinpoints just float around the vacant eye shapes as if they are not actually part of them. They can't bend around the eyes, can't dilate and certainly can't use cartoon license to enhance the appeal and expressibility of the characters.
Cal-Arts animators had a period where they used pin-point pupils. To me this made the characters very cold and unappealing. The animators relied on a handful of Disney eye expressions from the late 70s, but simplified them to the point of - I don't know...coldness. It makes it very hard to get into the characters. You can see it came from Disney, but eliminated what made Disney appealing in the first place. It's Disney without solid drawing or cuteness.
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Prime Time Cartoons
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Of course, big eyes and big heads won't guarantee your drawings will be appealing. They still have to be well-drawn in every other way, but these are 2 obvious traits that help make your characters fun to look at and they help grab people's attention and draw them into the characters' adventures and emotions (if they have any).
And it's not just the SIZE of the eyes that matters. The shape is important too, but I thought I would keep this post on one basic point.