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When we did the pilot for Ren and Stimpy, we couldn't afford extra people to do all the jobs that needed to be done, so Bob Camp and I painted most of the BGs.
He did the real ones, and I did mostly color cards.
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I always loved in Clampett's Baby Bottleneck, how there were many scenes with no BGs, just color cards behind the characters. In some scenes the BGs would change color on accents, like when a little hammer hits Daffy on top of his noggin, and his head changes shapes really fast.
Nico put this up:
http://www.happyhourshorts.com/gifs/daffyhit.gif
These quick color changes gave the accents more "oomph" and I thought, maybe I'll do it even weirder and put nutty patterns and blotches on the BGs.
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I wish I had known Art Lozzi was around!
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http://unofficialspumco.com/html/bighouseblues.html