Looks complicated, but is simpler if you understand the hierarchy...
The expression is the most important aspect of the drawing. It tells the story. It needs to be clear, and then wrap around the skull and jaw forms.
Then the rest of the details are subject to the positions of the expression and the skull and jaw. It's skin being pushed and pulled around the skull by the expression. George is a particularly fleshy man.
The same laws of hierarchy apply to the body and its details too. Same general logical reasoning.